Set just after Columbus’ discovery of the New World, Charise Castro Smith’s satirical and often anachronistic historical play covers a lot of territory. In 1504, Spain’s Queen Isabella is fretting about her empire and dying of some horrible plague, and she’s likely to be succeeded by her bratty daughter. Meanwhile, Isabella’s brilliant sister — a reclusive, atheist hunchback — is stuck in her bedroom thinking about cats, math and a Muslim lover. It’s a wild tale — just what you expect to see at Know Theatre — but this production comes to Over-the-Rhine from the drama program at the University of Cincinnati’s College-Conservatory of Music.
Through Oct. 24. $20; $10 rush seats. Know Theatre, 1120 Jackson St., Over-the-Rhine, 513-300-5669, knowtheatre.com.