When arthritis pain flares up or you experience ongoing backaches, it’s easy to reach for over-the-counter painkillers that promise quick relief. However, these can sometimes have harmful side effects. If you’re looking for a natural and effective solution, CBD cream for pain might be your answer.

These creams combine the therapeutic benefits of CBD with other natural ingredients to provide relief from muscle pain and joint stiffness. 

Most of them feature a non-greasy texture that won’t leave a sticky residue, making them perfect for daily use. Let’s take a look at some of the best CBD creams that can help manage your pain naturally.

Where To Buy CBD Creams

Best CBD Cream for Pain

FOCL Deep Relief Cooling Cream — Best Overall

  • May ease pain and discomfort

  • May help with muscle tension and soreness

  • Fast-acting benefits

  • Gluten-free and non-GMO formula

  • Light and pleasant scent

Features:

  • CBD Type: Broad spectrum hemp

  • CBD Concentration: 1000 mg and 2000 mg

  • THC Content: THC-free formula

  • Package Size: 100 ml

If you’re looking for a CBD cream that alleviates general aches and pains, FOCL Deep Relief Cooling Cream might be the perfect solution. This cream contains broad-spectrum hemp that interacts with your endocannabinoid system to provide relief and promote relaxation.

Besides that, this CBD pain cream is infused with other beneficial ingredients, including menthol, eucalyptus, wintergreen oil, camphor bark oil, arnica, and aloe vera which really sets it apart from other products.

FOCL Deep Relief Cooling Cream targets nerve pain at the source. The clinically proven ingredients like menthol and eucalyptus provide a cooling sensation for arthritis symptoms, while the wintergreen oil featuring anti-inflammatory properties adds a pleasant warmth that melts away all the pain and tension. Thanks to the included aloe vera which contains plenty of antioxidants, vitamins, and enzymes, this CBD cream for pain will keep your skin smooth and hydrated. 

The price of this pain relief ointment depends on the strength. A 1000 mg tube will cost you $39, while 2000 mg is available for $59. If you subscribe, it will save you 20%.

FOCL Deep Relief Cooling Cream has earned a 4.7 star rating from satisfied customers. One user raved, “This has been a go-to product for my wife’s back pain. We tried different stuff, but none works and lasts like this does.” Another mentioned they used it to relieve itchiness, while some found it effective relief from sudden neck and muscle pain.

FOCL is one the best brands that uses vegan-friendly and non-GMO ingredients for the formulation of its products. Besides pain cream, the brand has different products to improve focus, mood, and sleep quality. If you’re shopping for the first time, you’ll get 25% cashback on your order — which is a big plus for anyone who wants to invest in a quality cannabis product without spending much.

>>Check the best prices for FOCL Deep Relief Cooling Cream 

CBDistillery 1000mg Isolate CBD Relief Stick — Easiest Application

  • May nourish dry skin

  • May help with muscle pain

  • Hypoallergenic ingredients

  • Rigorously tested for quality assurance

  • Convenient stick application

Features:

  • CBD Type: CBD isolate 

  • CBD Concentration: 1000 mg

  • THC Content: THC-free formula

  • Package Size: 70 grams

This CBD cream for pain is packed with a solid 1000mg of CBD isolate, so it’s THC-free – no worries about feeling all kinds of high! It also contains menthol that provides an immediate cooling sensation which is perfect for quick relief.

If you’re someone who’s on the go — maybe you’re heading to the gym, the office, or out on an adventure — the CBDistillery 1000 mg Isolate CBD Relief Stick will be a real-life saver. This roll-on cream will help with muscle pain that comes from leading an active lifestyle.

Don’t want relief at the expense of dry, cracked skin? You’ll be glad to know that this CBD cream for pain also features shea butter and coconut oil that can help soothe and soften your skin instantly.

Originally priced at $65, CBDistillery 1000 mg Isolate CBD Relief Stick is now available at a discounted rate of $50. 

Customers can’t get enough of this CBD stick because it’s easy to use and keeps hands clean, thanks to the roll-on design. They appreciate the lack of an overpowering smell and find it very effective, with one user noting, “Soothes my tight & aching neck muscles quickly.” Affordable pricing and auto-ship options make it even better.

Founded in 2016, CBDistillery formulates its products with the help of expert botanists who use 100% clean ingredients for effective benefits. Each product — from its CBD oil to powder — is lab-tested for quality assurance. The brand also provides a 60-day satisfaction guarantee to its customers, so even if you don’t like your purchase, you have 60 days to claim a refund.  

>>Check the best prices for CBDistillery 1000 mg Isolate CBD Relief Stick

Cornbread Hemp CBD Lotion + Menthol — Best for Exercise-Induced Pain

  • USDA organic ingredients

  • Optimal CBD to THC ratio for enhanced effects

  • May help with sore muscles and joints

  • Designed for natural relaxation

  • Non-greasy formula

Features:

  • CBD Type: USDA organic CBD

  • CBD Concentration: 25 mg

  • THC Content: 1 mg THC

  • Package Size: 750 mg

With a 25:1 CBD to THC ratio, this CBD cream for pain features a balanced blend that targets pain without any psychoactive effects. The cream also contains some other soothing ingredients, including organic jojoba oil, argan oil, safflower oil, MCT oil, and more. The organic menthol gives a cooling effect that pairs wonderfully with its pain-relieving properties.

Did we mention that it’s made in a GMP-certified facility? This means it’s free from all major allergens — a big plus for allergy sufferers. 

Exercise-induced inflammation and soreness can make life tough — you can’t move, sit, or even laugh comfortably. This full-spectrum CBD lotion is crafted just for those post-workout woes.

Blending jojoba oil, emulsifying wax, and glycerin, Cornbread Hemp is infused with organic lemongrass oil, rosemary oil, menthol, and hemp extract to target pain. The quick-acting menthol gets to work immediately, cooling down your aches. For best results, apply after every 4-6 hours on the affected area to soothe those muscle strains and cramps. 

Cornbread Hemp’s lotion is priced at $39.99 which is a steal!

Cornbread Hemp CBD Lotion + Menthol does wonders. One review says, “I feel the difference in hip pain. So much relief. Thank you, Cornbread!” And there’s more love coming from another user who applied it on their knee and felt the pain ease up almost instantly. “The menthol smell is not overpowering like in some products,” they added. 

Cornbread Hemp offers a hemp-infused lotion that leans on USDA-certified organic ingredients. This makes it a great pick for those who prefer natural and organic products. The brand offers fast and discreet shipping, so you won’t have to worry about curious mailmen or nosy neighbors. Plus, there’s a 30-day money-back guarantee, ensuring a risk-free purchase.

>>Check the best prices for Cornbread Hemp CBD Lotion + Menthol

Tommy Chong’s 100MG Full Spectrum CBD Muscle Balm — Best for Muscle Stiffness

  • Contains Full Spectrum CBD

  • Soothes aching muscles

  • Relieves joint pain and swelling

  • Adjustable serving sizes

  • Convenient, mess-free application

Features:

  • CBD Type: Full spectrum hemp-derived CBD

  • CBD Concentration: 100 mg per container

  • THC Content: 0.3% 

  • Package Size: 60 ml

You can trust Tommy Chong to bring some quality CBD muscle balm your way. It boasts 100% full spectrum hemp-derived CBD to thrash pain. Alongside CBD, you get menthol and camphor for that classic cooling feeling. It also has cinnamon extract, chondroitin, glucosamine, and methylsulfonylmethane (MSM), offering anti-inflammatory and joint pain relief properties. 

Tommy Chong’s 100 mg Full Spectrum CBD Muscle Balm is perfect for anyone who experiences stiff joints and muscle soreness. It can help mitigate pain, reduce discomfort, and alleviate muscle stiffness when used alongside physical therapy. Thanks to its non-greasy formula, you won’t be left with that oily feeling on your skin. Plus, the scent is mild and pleasant, not overpowering. 

Coming at $29.95, this muscle balm is a budget-friendly option for treating mild aches or everyday soreness.

Tommy Chong’s muscle balm is a real crowd-pleaser. A user summed it up perfectly: “I use it on sore muscles (shoulders, neck, calves). I hurt my back in an accident at work & will occasionally rub balm on my back and thumb, which was fractured years ago. It’s very soothing & relieves pain. I’ve ordered 500mg balm & alternate between depending on my pain level. Would definitely recommend this product.”

Featured in different high-profile publications, including Forbes, CNN, High Times, and Newsweek, Tommy Chong’s product can naturally calm different issues that people face in day-to-day life, including muscle soreness, a grumpy mood, and stress. Its product contains only 0.3% THC to heal you without inducing any high. The brand also accepts various payment methods for a convenient shopping experience.

>>Check the best prices for Tommy Chong’s 100 mg Full Spectrum CBD Muscle Balm

CBD Pure CBD Topical Cream — Most Fast-acting Formula

  • Targeted pain relief formula

  • Fast-acting therapeutic benefits

  • Soothe and rejuvenate muscles

  •  Rapid absorption 

  • Lab-tested for pesticides, heavy metals, and harmful pathogens

Features:

  • CBD Type: Full spectrum CBD

  • CBD Concentration: 500 mg

  • THC Content: Less than 0.3% THC

  • Package Size: 90 grams tube

This cream combines CBD with plant-based botanicals like willow bark and menthol, making it a perfect no-fuss option if you want reliable pain relief without dodging a long ingredient list.

Tired of using creams and pain relievers that take ages to work? Try CBDPure CBD Topical Cream. Packed with full-spectrum CBD, Willow Bark, and cooling menthol, this cream is your go-to for when you need quick, reliable support, cutting down on recovery time. The advanced formula works with your body’s physiological processes to alleviate muscle soreness, stiffness, and discomfort so you can stay active and moving.

CBD Pure’s cream costs $39.99, but buying a 3-pack reduces it to $33 each, and a 6-pack drops it to $28 each.

Reviewers note that this cream isn’t the flashiest on the market, but it’s dependable when it counts. Some appreciate its fast-acting results, noting it works almost instantly, while others love that it’s lab-tested, which eliminates doubts about any negative effects.

As the name implies, CBDPure is all about offering natural and pure cannabis products, including oils, softgels, muscle creams, and pet products. There’s a separate FAQs section on the website that answers all your questions regarding CBD products. With its unconditional 90-day guarantee, there’s no risk in trying their products to see how they work for you.

>>Check the best prices for CBD Pure CBD Topical Cream

Exhale Wellness CBD Cream — Best for Recovering Athletes

  • Formulated with all-natural ingredients

  • Contains less than 0.3% THC

  • May alleviate bodily discomfort and pain

  • Ideal for active lifestyles

  • Excellent for recovering athletes

Features:

  • CBD Type: Full spectrum CBD

  • CBD Concentration: 1000 mg and 2000 mg

  • THC Content: 0.3% Delta 9 THC

  • Package Size: 59 ml

Exhale Wellness CBD cream features full spectrum CBD along with different all-natural ingredients, which can work together for a more effective result. The formula is 2018 Farm Bill compliant, which means it has less than 0.3% THC. 

Whether you’re a runner, a weightlifter, or an MMA fighter, pushing your body to its limits can lead to some serious discomfort. Exhale Wellness CBD Cream is specifically designed with athletes in mind, providing deep tissue relief that hits right where it hurts.

This cream contains a potent dose of CBD that helps reduce pain and inflammation. When you apply it to your skin, it absorbs quickly, getting deep into the muscles and tissues. You’ll feel the cooling effect almost instantly, and the relief that follows makes it easier to get back to doing what you love.

Exhale Wellness’s cream is the most premium option at $69.95, reflecting its high-end quality.

When it comes to the Exhale Wellness CBD Cream, people are seriously loving it. One person put it simply and straight to the point, “This cream is the absolute best. It’s the only one I’ve found that is 100% effective and actually takes the pain away.”

Exhale Wellness is a California-based brand that deals with premium cannabinoid blends, including Delta 8, Delta 9, HHC, THCV, and more. All of its products are vegan-friendly and cruelty-free, making it a top brand for ethical and health-conscious consumers. The brand also provides free shipping of over $80, which is a bonus for those stocking up on cannabis essentials.

>>Check the best prices for Exhale Wellness CBD Cream

What Is CBD Cream?

CBD cream is a topical product infused with cannabidiol (CBD), a compound derived from hemp plants. 

Unlike other CBD products that are ingested or absorbed internally, CBD cream is applied directly to the skin. It’s designed to target specific areas, making it popular for managing localized discomfort, inflammation, or skin conditions. 

These creams are often combined with other beneficial ingredients like essential oils, vitamins, and moisturizers, making them not only functional but also soothing and nourishing for the skin.

Differences Between CBD Cream and Other CBD Products

CBD cream stands out from other CBD products because of how it’s used and how it interacts with the body. Here’s how it compares to some common alternatives:

CBD Cream vs. CBD Oil

CBD oil is ingested or taken sublingually (under the tongue), delivering effects that are systemic, meaning they impact the entire body. 

In contrast, CBD cream is applied topically and works on a localized level, focusing on the specific area of application.

If you’re dealing with muscle soreness or joint pain, a CBD cream might be a better choice for targeted relief.

CBD Cream vs. CBD Capsules

CBD capsules are swallowed and processed through the digestive system, taking longer to produce effects. They provide consistent, long-lasting relief for general wellness or internal issues. 

On the other hand, CBD cream works faster in localized areas, making it ideal for pain relief in specific spots like the back, knees, or shoulders.

CBD Cream vs. CBD Edibles

Edibles like gummies or chocolates offer a tasty and discreet way to consume CBD, but like capsules, they provide systemic effects. CBD cream bypasses digestion entirely and offers more immediate, localized relief, without impacting the entire body.

CBD Cream vs. CBD Tinctures

Tinctures are typically taken sublingually or added to food and drinks for systemic effects. While they’re versatile and fast-acting, they don’t offer the same direct, localized benefits as a CBD cream. For addressing skin issues or specific areas of discomfort, cream is the more practical choice.

CBD Cream vs. CBD Patches

CBD patches deliver cannabinoids through the skin, offering a slow, steady release of CBD into the bloodstream for extended relief. CBD cream, by contrast, doesn’t enter the bloodstream but instead works directly on the skin and underlying tissues, making it faster for localized pain or inflammation.

>>Check the best prices for FOCL Deep Relief Cooling Cream

How CBD Cream Works for Pain Relief

CBD cream is particularly popular for pain relief because it offers direct and fast-acting benefits. Here’s how it works:

Mechanism of Action

When applied to the skin, CBD cream penetrates the top layers and interacts with nearby cannabinoid receptors. 

These receptors, part of the body’s endocannabinoid system, play a role in regulating pain and inflammation. By engaging with these receptors, CBD can reduce discomfort and promote a soothing effect in the affected area.

Interaction with the Endocannabinoid System

The endocannabinoid system (ECS) helps maintain balance in the body, influencing functions like pain perception, immune response, and inflammation. CBD cream interacts with CB1 and CB2 receptors located in the skin, focusing its effects on the application site. This localized approach allows for targeted relief without the systemic effects that come from ingesting CBD.

Benefits of Using CBD Cream for Pain

CBD cream offers several advantages for managing pain, making it a popular choice for those seeking natural, targeted relief. Here’s why it stands out:

Targeted Pain Relief

One of the biggest benefits of CBD cream is its ability to provide localized relief [1]. By applying the cream directly to the area of discomfort, you can target sore muscles, joints, or specific spots affected by pain, offering immediate soothing effects where you need them most.

Anti-inflammatory Properties

CBD is known for its anti-inflammatory effects, which can help reduce swelling and inflammation in areas experiencing discomfort [2]. This makes it particularly useful for conditions like arthritis, muscle soreness, or injury recovery.

Minimal Side Effects

Unlike some oral pain relief options, CBD cream has minimal side effects. Since it’s applied topically and doesn’t enter the bloodstream, it avoids potential issues like drowsiness or stomach upset, making it a safe option for most users.

Factors to Consider When Choosing the Right CBD Cream for Pain

Selecting the best CBD cream for pain involves evaluating a few key factors to ensure you’re getting a high-quality product that meets your needs.

CBD Concentration

The concentration of CBD in the cream determines its potency. Look for products with a higher CBD content if you’re dealing with intense or chronic pain. Beginners may start with lower concentrations and adjust as needed.

Ingredients

Check the ingredient list to ensure the cream contains natural, skin-friendly components. Avoid products with artificial additives or harsh chemicals, especially if you have sensitive skin. Additional ingredients like menthol, arnica, or essential oils can enhance the cream’s pain-relieving properties.

Third-Party Testing

A trustworthy CBD cream should be tested by an independent lab to verify its potency, purity, and safety. Look for products with a Certificate of Analysis (COA) that confirms the absence of harmful substances like pesticides, heavy metals, and solvents.

Brand Reputation

Choose brands with positive reviews, transparent practices, and a proven track record in the CBD industry. Well-regarded companies often prioritize quality and customer satisfaction, ensuring a reliable product.

How to Use CBD Cream for Pain Relief

Using CBD cream effectively involves applying it correctly and consistently for the best results. Here’s how to maximize its benefits:

Application Techniques

Clean the affected area with soap and water before applying the cream. Take a small amount and massage it gently into the skin until fully absorbed. 

Massaging not only helps the cream penetrate deeper but also promotes blood flow, which can enhance its effectiveness.

Recommended Dosage

Start with a small amount, especially if you’re new to CBD cream. You can gradually increase the quantity based on your pain level and how your body responds. Follow the manufacturer’s instructions for dosing, as different products may vary in strength.

Frequency of Use

For consistent relief, use CBD cream as needed or 2–3 times per day. If you’re dealing with chronic pain, regular application may provide more sustained benefits. Keep in mind that results may vary, and it may take some time to notice the full effects.

>>Check the best prices for FOCL Deep Relief Cooling Cream

Common Side Effects and Precautions

While CBD cream is generally safe for most people, it’s important to be aware of potential side effects and take necessary precautions to ensure safe use.

Skin Irritation

Some individuals may experience mild skin irritation, such as redness or itchiness, especially if they have sensitive skin or apply too much product. To avoid this, perform a patch test on a small area of skin before using the cream extensively.

Allergic Reactions

Certain ingredients in CBD cream, such as added essential oils or fragrances, could trigger allergic reactions in sensitive individuals. Always read the ingredient list and choose creams made with natural, hypoallergenic ingredients if you have allergies.

Interaction with Medications

Though CBD cream works locally and doesn’t usually enter the bloodstream, there’s still a small chance it could interact with medications, especially if applied in large quantities. Consult a healthcare professional if you’re taking prescription medications or have medical concerns.

Drowsiness or Fatigue

While uncommon, some users may feel mild drowsiness or fatigue after applying CBD cream. This is more likely if the product contains additional calming ingredients like lavender or chamomile. Use it at times when you don’t need to be highly alert.

Changes in Appetite or Weight

Although rare with topical use, some individuals might experience changes in appetite or weight as a result of prolonged CBD exposure. If you notice significant changes, it’s worth discussing with your healthcare provider.

FAQs

How Long Does It Take for CBD Cream to Work for Pain?

CBD cream typically starts working within 15–30 minutes of application. However, the exact timing may vary depending on the individual, the severity of pain, and the formulation of the cream.

Can CBD Cream Be Used for Chronic Pain?

Yes, CBD cream can be an effective option for managing chronic pain. Its localized application allows it to target specific areas of discomfort, making it ideal for conditions like arthritis, joint pain, or muscle soreness. Regular use may provide more sustained relief.

Is CBD Cream Legal?

CBD cream derived from hemp is legal in most regions as long as it contains less than 0.3% THC. However, laws may vary depending on your location, so it’s important to check local regulations before purchasing or using CBD products.

Can I Use CBD Cream Alongside Other Medications?

In most cases, CBD cream can be used alongside other medications since it works topically and has minimal systemic absorption. However, if you’re taking medications that interact with cannabinoids, consult your doctor before using CBD cream to ensure safety.

How Should I Store My CBD Cream?

Store your CBD cream in a cool, dry place away from direct sunlight and heat to maintain its potency and quality. Ensure the lid is tightly closed to prevent air and moisture from affecting the product. Refrigeration is also an option for long-term storage, especially in warm climates.

The Takeaway

After evaluating eight of the top CBD-infused creams for pain relief, it’s clear that the market offers several exceptional options. Among these, FOCL Deep Relief Cooling Cream stands out as the top choice, thanks to its effective formulation and high-quality ingredients.

Close behind, the CBDistillery 500mg CBD Balm also proves to be an excellent option, delivering substantial relief when it’s needed most. Both products are great examples of the potential CBD creams have to offer for targeted pain management.

We encourage you to revisit our top recommendations to find the product that aligns best with your needs and preferences. With so many great options available, you’re bound to find the right option for your needs!

References:

  1. Hall N, James B, Bhuiyan MAN, Crane E, Falgout C, Murnane KS. Topical cannabidiol is well tolerated in individuals with a history of elite physical performance and chronic lower extremity pain. J Cannabis Res. 2023 Mar 30;5(1):11. doi: 10.1186/s42238-023-00179-8. PMID: 36991501; PMCID: PMC10061782.

  2. Atalay S, Jarocka-Karpowicz I, Skrzydlewska E. Antioxidative and Anti-Inflammatory Properties of Cannabidiol. Antioxidants (Basel). 2019 Dec 25;9(1):21. doi: 10.3390/antiox9010021. PMID: 31881765; PMCID: PMC7023045.

This article appears in Feb 5-18, 2025.

I am a seasoned SEO writer and content marketer with over 17 years of experience, including expertise in the cannabis industry. I have worked with leading brands like HashDash and Sand Technologies, specializing...